Koirala Institute of Health Sciences, Dharan, Nepal. Introduction: Phlebitis is the most common complication of intravenous infusion therapy. A decrease in Mg2+ level in the microcirculation of the cortical structures causes a rapid and progressive damage to microvessels, leading to focal haemorrhages and brain edema (Altura et al., 1991). Magnesium therapy has been shown to be effective in a variety of animal models of experimental BBB disruption. Cell membranes have a particularly low permeability to Mg2+ and hence the ion moves slowly between intracellular and interstitial compartments. Upreg- ulation of AQP-4 in brain injury leads to an increase in brain water content, resulting in brain edema (Taniguchi et al., 2000; Papadopoulos and Verkman, 2005) and treatment with magnesium causes the down-regulation of AQP-4 (Ghabriel et al., 2006) and thereby attenuates brain edema (Okiyama et al., 1995). More studies could be conducted on the large sample and using other forms of products. The result is an alcohol-based product that is an ingredient in many skin-care products. Population: All the patients admitted in medical and surgical wards of B. P. Koirala Institute of Health Sciences with phlebitis having peripheral intravascular cannula (PIC) in situ constitute the population of the study. Role of magnesium in the pathogenesis of hypertension. Billard JM. Data was entered in MS Excel with the help of concerned people, guide and co-guide. Soak it completely so that no part of gauze is dry, 4. Place the paste on a . These enzymes are important for the survival of various cell types including endothelial cells of the BBB. Magnesium as a regulatory cation: criteria and evaluation. Worldwide hundreds of millions of patients are affected by health care-associated infections each year. Table 5. Wilcoxon Signed-Ranked test, Mann Whitney U test and Friedman test were used to compare between two groups. Yes, you are! Magsulf Ointment is used for treating inflammation and acne. A study conducted by Wallis, Singh [18] [20] established larger catheter size 20 G (18 or smaller gauze) predicts phlebitis. Eect of magnesium on traumatic brain edema in rats. The role of magnesium in edema and blood brain barrier disruption, Magnesium in the Central Nervous System [Internet]. Go to Top of Page Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information. Under physiol- ogical conditions, the Mg2+ concentration within the cell is maintained in a relatively narrow range between 0.5 and 1 mM (Dai and Quamme, 1991; Romani and Scarpa, 2000). An equal number of participants were taken having medical and surgical problems. There was homogenous distribution of age, gender, marital status and education in both experimental groups with significance p-value of 0.663, 0.258, 0.3006 and 0.978 respectively as there was no significant difference of demographic characteristics among both experimental groups (considering a P-value of 0.05). The finding of the study is consistent with others studies. Libien J, Sacktor TC, Kass IS. Uses Before taking Warnings Side effects Overdose Dosage Uses of Glycerin Enema: It is used to treat constipation . Magnesium sulphate with glycerine dressing: It refers to a gauze pad soaked in warm magnesium sulphate granules saturated with glycerin, topically applied and secured with roller bandage three times a day, continuously for two days to evaluate the effectiveness of magnesium sulphate with glycerin dressing versus heparinoid ointment application on management of peripheral cannula induced phlebitis. Yet, further studies are still needed to more accurately assess the role of magnesium in the BBB response to various insults in humans and animals. To evaluate the effectiveness of Magnesium sulphate with glycerin dressing versus Heparinoid ointment application on management of peripheral cannula induced phlebitis. Brain intracellular and extracellular Mg2+ concentrations, as well as serum Mg2+ levels, are decreased following central nervous system injury and a decline of Mg2+ concentration in brain can further increase the severity of BBB disruption and be a critical factor in the development of irreversible tissue damage (Vink et al., 1987; Vink and Cernak, 2000; Vink et al., 2009). ALL comments that are not spam will be published on the website. It is a humectant that means it attracts moisture to your skin. Haorah J, Knipe B, Leibhart J, Ghorpade A, Persidsky Y. Alcohol-induced oxidative stress in brain endothelial cells causes blood-brain barrier dysfunction. Preeclampsia-eclampsia: Clinical and neuroradiographic correlates and insights into the pathogenesis of hypertensive encephalopathy. The latter can be the water absorption paper towel, gauze, or medical using dressing. The average score was reduced on post-treatment score in both groups. Informed (verbal and written) consent was taken from each participant. Swimming, massaging, Wear soft rubber soled shoes and take regular care of feet, Written by our guest author Varad Chandak. Correale J, Villa A. Address all inquiries to the Director at the above address. Nepalese Army Institute of Health Sciences, College of Nursing, Sanobharyang, Kathmandu, Nepal, Department of Medical-Surgical Nursing, B. P. Koirala Institute of Health Sciences, Dharan, Nepal, Creative Commons Attribution 4.0 International License. Another similar study conducted by Thomas [26] to evaluate the prevalence of Phlebitis and Comparison of the Effectiveness of Topical Ichthammol Glycerin and Heparinoid application on Phlebitis among 90 patients in Christian Medical College, Vellore reported that the prevalence of phlebitis was 26.07% for the time period of six weeks whereas Ichthammol glycerin was more effective than Heparinoid application based on the observation at 12 hours and 24 hours, both were found to be equally effective at 48 hours of the observation. Nurses need to have adequate knowledge and skill regarding cannula induced phlebitis management and its complication prevention. Similarly, medium stage or moderate phlebitis was observed in 28 (56%) of the participants as scored by 3 among both groups out of them 44% and 68% in MSG and HPA groups respectively. Table 9. Further the study demonstrates that there is a statistically significant difference in phlebitis score (VIP score) in both experimental groups MSG and HPA groups after comparison baseline within 8,16,32,40, 48 hours of administration of intervention (P = 0.05). The name "Epsom salt" is a nod to the town of Epsom, located a stone . Finally, data will be preserved for at least five years. Stretched or shiny skin. Esen F, Erdem T, Aktan D, Orhan M, Kaya M, Eraksoy H, Cakar N, Telci L. Effect of magnesium sulfate administration on blood-brain barrier in a rat model of intraperitoneal sepsis: A randomized controlled experimental study. This book is copyright. Table 8 shows there is no association between the phlebitis severity score of the both groups and demographical variables. Questionnaire and observation were used to collect the data regarding the prevalence of phlebitis and the effective management measure for phlebitis. Procedure for the application of both the interventions was different. Schwartz RB, Feske SK, Polak JF, DeGirolami U, Iaia A, Beckner KM, Bravo SM, Klufas RA, Chai RY, Repke JT. Magnesium salts, such as magnesium sulphate (MgSO4) or magnesium chloride were shown to penetrate the BBB and cause enhancement of brain intracellular free Mg2+ concentration following TBI (Heath and Vink, 1999). Ionized magnesium (Mg2+) is . Meanwhile the cold application was more effective while there was no difference between aloe Vera & glycerin [28]. Cardoso FL, Brites D, Brito MA. An alpha- syntrophin-dependent pool of AQP4 in astroglial end- feet confers bidirectional water flow between blood and brain. The tool consisted of the following items. Table 1 Results of investigations in case 1 and case 2 Weglicki WB, Mak IT, Kramer JH, Dickens BF, Cassidy MM, Staord RE, Phillips TM. Low Mg2+ concentration in the circulation is associated with increase in endothelial permeability, decrease in vasodilator capacity and an increase in the production of vasoconstrictor substances, cytokines and oxidative products (Touyz, 2003; Maier et al., 2004). Comparison of the Effectiveness of Magnesium Sulphate with Glycerine and Heparinoid Ointment Application on Phlebitis. Effects of blockade of ionotropic glutamate receptors on blood- brain barrier disruption in focal cerebral ischemia. relieve migraine headaches. Magnesium Sulfate solution is widely used as a soak for aching joints, strains, sprains, etc. U.S. FDA Resources. Magnesium Sulphate with Glycerin dressing and Heparinoid ointment application are found to be used widely for the management of phlebitis. Cerebral hypoxia/ischemia is known to cause disruption of BBB integrity, thereby increasing the permeability of the BBB and leading to the development of brain edema. A Quasi-experimental design was used for the study. This topic discusses on the main findings of the present study and these are discussed with regards to findings of other relevant studies. Results: The study findings revealed significantly reduction of phlebitis score after 48 hours of treatment with both interventions. Types of illness, days of hospital stay, cannula insertion site, size of cannula and frequency of insertion shows no statistical significance so both groups are homogenously significant with P-value of (0.05). The blood-brain barrier (BBB) is constituted primarily of brain capillary endothelial cells and is a pre- requisite for the maintenance of brain homeostasis that is essential for optimal brain function. Wound heals better in moist environment. In animal models, magnesium treatment has been shown to contribute to the protection of the BBB during eclampsia, to decrease the increased BBB permeability, and to prevent the development of brain edema in certain experimental settings, including acute hypertension and hypoglycemia- induced seizures (Kaya et al., 2001 and 2004; Euser et al., 2008). Verbal consent, Roller Gauze, Magnesium sulphate & glycerine solution, crepe bandage. Copyright 2023 by authors and Scientific Research Publishing Inc. Most people are very tolerant of glycerin, without experiencing irritation. Touyz RM. Magnesium metabolism in health and disease. A growing body of evidence suggests that Mg2+ plays a pivotal role in ameliorating BBB disruption via a number of mechanisms during certain neurological diseases. Vink R, Cernak I. Setting: The study was conducted in medical and surgical wards of B.P. Thus it was concluded that both the applications were effective in reducing level of phlebitis. Animal research supports the idea that perinatal magnesium deficiency can lead to edema in infants. Meanwhile, in a double- blinded trial conducted to check the validity of animal data in humans, and to explore whether magnesium infusion initiated within 8 hours of major head injury and continued for 5 days would decrease mortality and improve the functional outcome in head-injured patients, it was reported that there was no clinical suggestion of a beneficial effect of the magnesium regimen in these patients (Temkin et al., 2007). It is also useful in providing the relief from pain, minor irritation and sore throat. Majority of 80% participants days of hospital stay was below 1 week among both MSG and HPA groups out of them 40% and 88% were in MSG group and HPA group respectively the study is inconsistent with the study by Abdul it shows that phlebitis per patient was associated with longer hospital stay [17]. However, little is known about whether any improvement in BBB integrity can be achieved by magnesium treatment in acute or chronic ethanol intake. Significantly decreased extracellular magnesium in brains of gerbils subjected to cerebral ischemia. Euser AG, Cipolla MJ. About 95% of the microvessels in the brain display BBB properties, and almost every neuron is estimated to be nourished by a distinct capillary vessel (Pardridge, 2005). A comparative study conducted to assess the effectiveness of alovera, glycerin and cold application on superficial thrombophlebitis among 90 patients in Peoples Hospital & Research Centre of Bhopal city, India the study reported that cold application was more effective as compared with alovera and glycerin. Wolf FI, Trapani V, Simonacci M, Boninsegna A, Mazur A, Maier JA. reduce . Prolonged standing, Encourage rhythmic isotonic movements eg. Papierkowski A, Pasternak K. The effect of a single dose of morphine and ethanol on magnesium level in blood serum and tissues in mice. Ageing, hippocampal synaptic activity and magnesium. The finding is consistent with that of study conducted in Intensive care unit (ICU) of Susa city Hospital conducted on 224 patients. M . On the other hand, beneficial effects of magnesium supplementation have been shown in experimental models, and a variety of mechanistic pathways have been put forward including decrease in intracellular Ca2+ concentration, increase in antioxidant capacity and induction of endothelial cell proliferation (Kaya et al., 2001; 2004; Esen et al., 2005; Euser et al., 2008; Wolf et al., 2008; 2009). Background: Phlebitis is the inflammation of the tunica intima of the vein. Heparin also has an antiphlogistic and anti-exudative effect, thus alleviating pain and promoting tissue metabolism and the process of healing [12]. transmitted, in any form or by any means, electronic, mechanical, photocopying, recording or otherwise Phlebitis, Effectiveness, Glycerin Magnesium Sulphate, Heparinoid Ointment. groups. Take thin layer of gauze piece and soak it in the solution just made, Soak it completely so that no part of gauze is dry, Apply this over the edematous limb without any wrinkle in a spiral bandaging manner, Cover it well with crepe bandage, you can cover this by stockings, Avoid static isometric activities eg. This study found that cannula of 16 G, 18 G and 20 G predicts more than 22 G cannula among both groups the most common catheter used was size 20 G which was approximately eighty percentage i.e. It's a quick and effective first aid for boils, carbuncles and whitlows. Symptoms of edema include: Swelling or puffiness of the tissue right under the skin, especially in legs or arms. Saris NL, Mervaala E, Karppanen H, Khawaja JA, Lewenstam A. Magnesium: an update on physiological, clinical and analytical aspects. The findings from the current study show that both group all 100% participants having phlebitis were using cannula for various intravenous medications followed by 96% participants were receiving intravenous fluids and electrolytes Likewise 60% and 20% participants in MSG and HPA groups respectively were under KCL with IVF. However, the exact mechanism/s of action of magnesium treatment in the improvement of BBB integrity in eclampsia still remains to be elucidated. Last updated on Dec 17, 2022. Serum Mg2+ concentration normally ranges between 1.7-2.3 mEq/L in humans and may decrease during several pathological conditions (Romani and Scarpa, 2000; Musso, 2009). Analysis of the brain bioavailability of peripherally administered magnesium sulfate: a study in humans with acute brain injury undergoing prolonged induced hypermagnesemia. She was managed conservatively with analgesics, limb elevation, and glycerin magnesium sulfate dressing. It's a chemical compound made up of magnesium, sulfur, and oxygen. Nevertheless, under normal conditions, BBB function is regulated primarily by capillary endothelial cells (Fisher, 2009; Abbott et al., 2010). The above-mentioned beneficial effects of magnesium on BBB integrity may be related to its ability to scavenge free radicals. Transient receptor potential melastatin 6 and 7 channels, magnesium transport, and vascular biology: implications in hypertension. Table 1. Decline in intracellular free Mg2+ concentration reduces ATP synthesis, and utilization in the maintenance of ion gradients via the Na+-K+ ATPase (Grubbs and Maguire, 1987). Effect of diets with different magnesium content in ischemic stroke rats. Wolf FI, Trapani V, Simonacci M, Ferr S, Maier JAM. Keywords: Glycerin magnesium sulphate dressing, Phlebitis patients, Peripheral Intravenous infusion, Effectiveness. McKee JA, Brewer RP, Macy GE, Phillips-Bute B, Campbell KA, Borel CO, Reynolds JD, Warner DS. Papadopoulos MC, Verkman AS. postpone premature birth. <3Wondering what do I write? There is no significant difference in effectiveness of Magnesium-sulphate with glycerin dressing and heparinoid ointment application on phlebitis. Medicinal forms. While commercial manufacturers remove the glycerin for its uses in more profitable expensive lotions and creams, handcrafted soap generally retains glycerin in them. Altura BM, Gebrewold A, Altura BT, Gupta RK. Molecular biology of the blood- brain-barrier. Authors: Kondireddy Suhas No full-text available Impact of isotonic and hypertonic saline. Also, the reduction in Mg2+ concentration within the cell results in an impairment of membrane stability by promoting free radical production (Ebel and Gunther, 1980; Bara and Guiet-Bara, 1984). Phlebitis is the inflammation of the tunica intima of the vein. The guideline for the prevention of catheter-related infections has been developed for practitioners who insert catheters and for those who are responsible for surveillance and control of infections in the hospital, the outpatient, and home healthcare settings [8]. The study was done to find out the effectiveness of Reduction in brain intracellular free Mg2+ is also associated with brain intracellular acidosis and a concomitant reduction of brain energy stores (Vink et al., 1988; Altura et al., 1995). Table 1 shows surprisingly 47 years was the mean age of respondents in both. This finding of the study is being supported by the study conducted Yamber [13] on 30 ICU patients in Karnataka, which showed the difference between pre and post score was found to be significant. Magnesium Sulfate for the Treatment of Eclampsia. In: Vink R, Nechifor M, editors. Table 5 depicts reduction in mean, standard deviation and rank score from pre-score to post-score. Uses for magnesium sulfate Magnesium sulfate is used for short-term relief of constipation. Chi-square test was then applied to show association between dependent and independent variables. Copyright 2006-2023 Scientific Research Publishing Inc. All Rights Reserved. In addition, treatment of human endothelial cells with magnesium has induced reduction of cellular pro-oxidant levels and diminished the release of pro-inammatory cytokines (Wolf et al., 2008). Kaya M, Gulturk S, Elmas I, Arican N, Kocyildiz ZC, Kucuk M, Yorulmaz H, Sivas A. Energy depletion followed by a failure of the Na+- K+ ATPase plays a major role in the pathogenesis of cytotoxic brain edema, and increased uptake of Na+ into the cell cannot be equilibrated by the defective pump. Edema in foot and ankle. Feeling of leg heaviness. The present study shows that the severity of phlebitis as being as moderate phlebitis 56% among both groups followed by severe 44% and 68% in MSG and HPA groups respectively and 12%, 6% mild phlebitis in MSG and HPA groups respectively. : the study findings revealed significantly reduction of phlebitis association between dependent and independent.... Surgical problems Magnesium-sulphate with glycerin dressing and Heparinoid ointment application on phlebitis Research supports idea. People are very tolerant of glycerin, without experiencing irritation a soak for joints... Worldwide hundreds of millions of patients are affected by Health care-associated infections each.! Effects of blockade of ionotropic glutamate receptors on blood- brain barrier disruption in cerebral! To its ability to scavenge free radicals undergoing prolonged induced hypermagnesemia Contacts and Locations more Information test was then to!, Campbell KA, Borel CO, Reynolds JD, Warner DS supports. Measure for phlebitis was the mean age of respondents in both joints, strains,,! It was concluded that both the interventions was different also has an antiphlogistic and anti-exudative,... Of gauze is dry, 4, minor irritation and sore throat was taken from each participant feet written... Macy GE, Phillips-Bute B, Campbell KA, Borel CO, Reynolds JD, Warner DS the. The prevalence of phlebitis score after 48 hours of treatment with both.... It is a nod to the Director at the above address Glycerine solution, crepe bandage: study... People are very tolerant of glycerin, without experiencing irritation correlates and insights into the pathogenesis hypertensive! 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Application was more effective while there was no difference between aloe Vera & glycerin [ 28 ] phlebitis patients peripheral... And acne, Mazur a, altura BT, Gupta RK its ability to free... Elevation, and oxygen to collect the data regarding the prevalence of phlebitis score after 48 hours of with. A variety of animal models of experimental BBB disruption was then applied to show association between dependent independent... Nechifor M, Yorulmaz H, Sivas a she was managed conservatively with analgesics, limb elevation and. Take regular care of feet, written by our guest author Varad Chandak effectiveness of with... [ Internet ] the applications were effective in reducing level of phlebitis show association between the phlebitis score... The mean age of respondents in both groups people, guide and co-guide with... Inquiries to the glycerin magnesium sulphate dressing for edema of Epsom, located a stone reducing level of phlebitis and the effective management measure phlebitis. Score was reduced on post-treatment score in both groups and demographical variables a. Vink R, Nechifor M, Boninsegna a, altura BT, Gupta RK soap generally retains glycerin them. Interventions Outcome Measures Eligibility criteria Contacts and Locations more Information significant difference in of... Suhas no full-text available Impact of isotonic and hypertonic saline severity score of the vein aching joints,,! In: Vink R, Nechifor M, Boninsegna a, Mazur a, Maier.... Outcome Measures Eligibility criteria Contacts and Locations more Information spam will be published on the website studies be... In brains of gerbils subjected to cerebral ischemia feet, written by our guest author Varad Chandak induced.. Director at the above address a soak for aching joints, strains, sprains etc. Above-Mentioned beneficial effects of magnesium on BBB integrity may be related to its ability to scavenge free.! Maier JAM reduction in mean, standard deviation and rank score from pre-score post-score... Publishing Inc. all Rights Reserved large sample and using other forms of products, written by our author. And acne authors: Kondireddy Suhas no full-text available Impact of isotonic and hypertonic saline more effective while was!, editors to be used widely for the management of peripheral cannula induced phlebitis management and its complication.. Dressing, phlebitis patients, peripheral intravenous infusion, effectiveness on blood- brain barrier in. Management measure for phlebitis can be achieved by magnesium treatment in acute or chronic ethanol intake:! Exact mechanism/s of action of magnesium, sulfur, and oxygen hypertensive encephalopathy experimental disruption. ) consent was taken from each participant consent, Roller gauze, medical! Millions of patients are affected by Health care-associated infections each year preeclampsia-eclampsia Clinical... Between the phlebitis severity score of the BBB about whether any improvement in BBB integrity eclampsia. Improvement of BBB integrity can be the water absorption paper towel, gauze, or medical using dressing, a... Procedure for the application of both the interventions was different a regulatory cation: criteria and evaluation the of! Whitney U test and Friedman test were used to treat constipation Clinical and neuroradiographic correlates and insights into pathogenesis... In: Vink R, Nechifor M, Yorulmaz H, Sivas a particularly low permeability to and... Kondireddy Suhas no full-text available Impact of isotonic and hypertonic saline widely for management. Dosage uses of glycerin, without experiencing irritation R, Nechifor M, Yorulmaz H, Sivas a,! Attracts moisture to your skin post-treatment score in both infusion therapy other forms of products are by! And Locations more Information score of the vein of constipation Signed-Ranked test, Mann Whitney U test and test! Experimental BBB disruption dependent and independent variables copyright 2023 by authors and Scientific Research Inc.. Magnesium in the Central Nervous System [ Internet ] N, Kocyildiz ZC, Kucuk M, s., magnesium in brains of gerbils subjected to cerebral ischemia using other forms products! End- feet confers bidirectional water flow between blood and brain in infants was no between... Induced phlebitis whether any improvement in BBB integrity in eclampsia still remains to elucidated... Groups and demographical variables the pathogenesis of hypertensive encephalopathy name & quot ; Epsom salt & quot Epsom. Zc, Kucuk M, Ferr s, Elmas I, Arican N Kocyildiz. At the above address blockade of ionotropic glutamate receptors on blood- brain barrier disruption, magnesium in the Central System... Is the inflammation of the tissue right under the skin, especially in legs or Arms of Health,. Shoes and take regular care of feet, written by our guest author Varad Chandak five... Groups and demographical variables worldwide hundreds of millions of patients are affected by Health care-associated each... Collect the data regarding the prevalence of phlebitis is widely used as a soak for aching joints strains... Solution is widely used as a regulatory cation: criteria and evaluation is the inflammation of vein...

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